ClubFEM was started in late 1992 by Head Mistress Dee and slave gene to provide an organization for Women and men with an interest in Female Domination.

Originally, ClubFEM activities consisted of socializing, wearing fetish apparel, showing off BDSM (bondage/discipline/sadomasochism) equipment, and taking posed photos. There was very little dungeon play if any at all. At this time, all correspondence was conducted by snail mail and slave gene wrote several articles that were published in magazines. A quarterly newsletter was mailed out to interested individuals. Head Mistress Dee and slave gene attended parties held by other fetish groups in Houston but found that they were mostly male dominant/Female submissive events. However, at these events, they were able to meet other people who were also interested in a strictly Female dominant/male submissive venue and the ClubFEM membership began to grow.

With the advent of the internet, the ClubFEM website was created. Slave gene as official secretary for Head Mistress Dee became inundated with requests for information and membership. To their surprise, Head Mistress Dee and slave gene realized there were thousands of individuals, both male and Female, who were dedicated to Female domination worldwide.

After founding ClubFEM and presiding as Grand Head Mistress for 14 years, Mistress Dee formally announced Her retirement in August 2005. She expressed her gratitude that Mistress Ella and Mistress Modesty (aka LustyLadyDom) had taken leadership in ClubFEM International and announced that it is with Her blessings that Ms. Modesty and Ms. Ella replace Her as Headmistresses for the Houston chapter as well. In May 2007, slave gene retired as the secretary of ClubFEM Houston to move to Jacksonville, FL to live with his new Mistress/Owner and to begin the now thriving ClubFEM of Northeast Florida. In May 2009 Mistress Modesty resigned her position as co-Head Mistress due to the increasing demands of her professional career. Head Mistress Ella remains the Head Mistress of ClubFEM Houston and ClubFEM International.

There are ClubFEM chapters in locations throughout the world and interested parties should contact ClubFEM International for the chapter nearest them.

The New York City chapter of ClubFEM was established in 2007 by Mistress Reina, who was then Head Mistress. The very first ClubFEM NYC munch was held on Friday, January 11, 2008. Today, the chapter is guided by a Head Mistress and an Advisory Board, which includes a representative from the submissive male membership.  These are all volunteer positions.